Serum interleukin-6 and mean platelet volume in pediatric pneumonia
Abstract: In pneumonia,
interleukin (IL)-6 is released in response to inflammation. Interleukin-6
stimulates megakaryocyte maturation, leading to larger platelets being released
into the circulation. Platelet size is measured as mean platelet volume (MPV).
The MPV may also be affected by nutritional status and smoking.
Objective To assess for a possible relationship between serum IL-6
concentration and MPV, including smoking and nutritional status as confounding
factors, in children with pneumonia.
Methods An analytic, observational study with cross-sectional design and
consecutive sampling of children aged 2 to 59 months with a clinical diagnosis
of pneumonia was conducted from November 2013 to March 2014 in Dr. Hasan
Sadikin General Hospital and two network hospitals. All patients underwent
routine complete blood counts including MPV and measurement of serum IL-6
concentration using an enzyme-linked immunosorbent assay (ELISA) technique.
Regression linear analysis was used to assess the relationship between MPV and
IL-6, passive smoking, and nutritional status.
Results There were 67 patients enrolled in the study. Subjects’ mean
serum IL-6 concentration was 49.3 (SD 78.3) pg/mL, and mean MPV was 9.2 (SD
0.9) fL. The regression model for MPV was 7.531 + 0.662 (passive smoking) +
0.276 (weight per age) + 0.009 (IL-6).
Conclusion There was a relationship between IL-6 serum concentration and
MPV in children with pneumonia.
Author: Melisa Lilisari, Heda
Melinda Nataprawira, Dida Akhmad Gurnida
Journal Code: jpkedokterangg160026