QT Interval Prolongation Associated with Amiodarone Use in Cipto Mangunkusumo Hospital, Jakarta
ABSTRACT: to evaluate the
incidence of QTc interval prolongation associated with the use of amiodarone,
as well as factors that influence its occurrence. Methods: this was a
descriptive retrospective study conducted from November 2010 until December
2011 using medical record of patients at ICCU Cipto Mangunkusumo Hospital from
2004-2011. Four groups of patients were included: (1) patients receiving
amiodarone and other drugs causing which can cause QTc prolongation, (2)
patients receiving amiodarone and other drug not causing QTc prolongation, (3)
patients receiving drugs which can cause causing QTc prolongation, (4) patients
not receiving amiodarone, nor other drugs which can cause causing QTc
prolongation (served as control group). Difference of QTc interval within the
same group was analyzed with paired t-test or Wilcoxon matched-pairs test.
Between groups comparison were performed with Kruskal Wallis test. The influence
of other factors (sex, age, heart failure, liver disorder, electrolyte
imbalance) on QTc prolongation was analyzed using multiple regression. Results:
QTc interval prolongation in groups 1, 2, and 3 were respectively 65.5%, 63.3%,
56.6%, which were signifcantly different from control group (24.4%);
Hypernatremia and hypertension were revealed as signifcant risk factor for QTc
prolongation. Mortality occurred in 3, 4, and 4 patients in group 1, 2, and 3
respectively, and none in group 4. Conclusion: QTc interval prolongation
occurred in association with amiodarone and other drugs known to prolong QTc
interval. Hypernatremia and hypertension were shown as signifcant influencing factor
of QTc interval prolongation.
Author: afrialdi, Teresia G.
Kurniawan, Arini Setiawati, Lukman H. Makmun
Journal Code: jpkedokterangg140292