Hemostatic Status of Pre and Post Intracoronary Injection of Peripheral Blood Stem Cells in Patients with Recent Myocardial Infarction
ABSTRACT: to investigate
hemostatic parameter changes, such as platelet aggregation, blood and plasma viscosity,
prothrombin time, APTT, CRP and fbrinogen, before and after administration of
stem cell therapy. Methods: a total of 24 patients were enrolled. Peripheral
blood stem cells (PBSCs) were harvested and injected into the infarct-related
artery after 5 consecutive days of G-CSF administration. Recombinant human erythropoietin
was administered at the time of intracoronary PBSCs injection. Results: we were
able to evaluate 11 from 24 of patients regarding hemostatic status pre–post
stem cell injection. There were no signifcant difference between baseline vs 3
months in spontaneous aggregation (p=0.350), PT (p=0.793), aPTT (p=0.255) and
TT (p=0.254). There were also no signifcant difference between baseline vs 3
months in plasma viscosity (p=0.442) and blood viscosity (p=0.843).
Nevertheless the patient who had their blood and plasma viscosity above or
below normal laboratory range return to normal level after the treatment. Both
PT and APTT also show normalization value. Both Fibrinogen and CRP level show
signifcant decrease between baseline and 3 months after treatment (p=0.009) and
(p=0.04) respectively. Conclusion: combined G-CSF and EPO basedintracoronary
infusion of PBSCs may open new perspective in the treatment of hypercoagulable
state post AMI.
Author: Cosphiadi Irawan dkk
Journal Code: jpkedokterangg140266
