Genetic risk factor APOEε4 associates with plasma amyloid beta in amnestic mild cognitive impairment and alzheimer’s disease
Abstract: APOEε4 is a strong
genetic risk factor for Alzheimer’s disease (AD). AD itself has been associated
with reduced Aβ clearance from the brain and plasma. Understanding the
potential pathogenic link between APOEε4 and plasma Aβ might allow for earlier
identification of people at risk of developing AD. The aim of this study is to
find out the correlation between APOEε4 and plasma Aβ in amnestic mild
cognitive impairment (aMCI) and AD patients.
Methods: This is a comparative cross-sectional study of patients
attending a memory clinic in Siloam Hospital Lippo Karawaci, Tangerang, during
the period of 2013-2014. Subjects were categorized into three categories:
normal aging, aMCI, and AD. We performed blood test to examine APOEε4, plasma
Aβ4o level, and plasma Aβ42 level. All data analyses were performed using
correlation test and logistic regression.
Results: Sixty subjects (normal aging = 23, aMCI = 17, AD = 20) were
included. There were 19 (31.7%) subjects with APOEε4 positive. Subjects
carrying ε4 allele were more likely to have AD by 3.9-fold than subjects with
APOE ε4 allele negative. There is a significant difference between the mean of
plasma Aβ40 in aMCI group and AD group. We also found correlation between
APOEε4 (+) and higher plasma Aβ42 (p<0.05).
Conclusion: There is a correlation between APOEε4 and plasma Aβ42 level,
which supports the hypothesis that this genetic isoform accelerates the rate
and progression of AD through Aβ-dependent pathways.
Author: Rocksy F.V. Situmeang,
Eka J. Wahjoepramono, Cahyono Kaelan, Jan S. Purba, Budhianto Suhadi, Suryani
As'ad, Amiruddin Aliah, Ilham J. Patellongi, Syarifuddin Wahid
Journal Code: jpkedokterangg160134
