FARMAKOGENETIK PENGOBATAN BETA 2 AGONIST DAN STEROID PADA PENDERITA ASMA
Abstract: In the worldwide
about 300 million people have asthma. β-2 agonists and steroids are widely
prescribed drugs in the treatment of asthma. Different responses raises the
suspicion of a genetic infiuence on the hosts response to the treatment of this
disease. The purpose of this review is to provide a comprehensive understanding
of the infiuence of genetic factors on the treatment of asthma. This review is
done by the method in Pubmed search using keywords Pharmacogenetic asthma;
polymorphism beta agonist AND asthma. The analysis shows that there are several
genes that affect treatment response. ADRB2 gene affects the bronchodilatation
response for asthmatics treated with β-2 agonist. CRHR1 gene polymorphism, Glucocorticoid-complex
genes, and CER2 genes and TBX21 genes affect the response to corticosteroids
inhalers.
Penulis: EM Sutrisna
Kode Jurnal: jpkedokterandd140562
