Association of resistin level with acanthosis nigricans in obese adolescents
Abstract: Childhood obesity is
associated with increased risk of cardiovascular diseases and metabolic
syndrome, such as insulin resistance. Clinically, insulin resistance may be
manifested as acanthosis nigricans. Resistin has a biological activity that is
important in glucose and lipid metabolisms and closely related to the incidence
of insulin resistance.
Objective To find out the association of resistin level with scale of
acanthosis nigricans in adolescents obesity.
Methods A cross-sectional study was conducted on 53 obese adolescents
with acanthosis nigricans in senior high schools in Padang, West Sumatera.
Degree of acanthosis nigricans was assessed using scale of Burke and then
plasma resistin level was performed with ELISA. Data were analyzed using ANOVA
and post-hoc test.
Result The mean of resistin level in obese adolescents was 14.21 (SD
7.43) ng/dL. High resistin level was found in scale of acanthosis nigricans 2,3
and 4 (P=0.0001). Obese adolescents with severe degree of acanthosis nigricans
has higher resistin level compared to milder acanthosis nigricans.
Conclusion In obese adolescents, the higher degree of acanthosis
nigricans, the higher level of plasma resistin.
Author: Dini Noviarti, Eka Agustia
Rini, Fadil Oenzil
Journal Code: jpkedokterangg160022
