Aspirin as a Chemopreventive Agent for Cancer: a New Hope?
ABSTRACT: inflammation has
been shown to play a major role in the pathogenesis of cancer. Inflammatory
process activates the immune system through pro-inflammatory mediators and
subsequent triggers transformation into malignant cells. Some tumors or cancers
has been associated with chronic infections, such as hepatitis B and C viruses
(hepatocellular carcinoma), human papilloma virus (cervical cancer),
Helicobacter pylori (gastric cancer and lymphoma), and prostatitis (prostate
cancer). A considerable study have investigated the benefits of aspirin for the
prevention and treatment of cancer or tumors. Objectives: This paper aims to
describe the relationship between inflammation and cancer incidence, so that
use of aspirin as an anti-inflammatory agent is a rational choice in the
treatment and prevention of cancer. Conclusion: Aspirin potential for
chemoprevention of various types of cancer. Considering the high risk of side
effects of aspirin, aspirin is not intended as a routine therapy to prevent the
occurrence of cancer.
Author: Isnatin Miladiyah
Journal Code: jpkedokterangg150297
