Uji Senyawa Taurin Sebagai Antikanker Terhadap Jumlah Sel-Sel Leukosit Dan Sel-Sel Eritrosit Mencit (Mus Musculus L.) yang Diinduksi Benzo (Α) Pyren Secara In Vivo
Abstract: The aim of this
research was to determine the effect of taurine supplementation on the total
count of leucocyte cells and erythrocyte cells of mice that have been induced
to benzo (α) pyrene in vivo. The parameters of this experiment were the total
count of leucocyte cells and erythrocyte cells of mice (Mus musculus L.). This
experiment was conducted in a complete randomized design by using six
treatments, each in five replications. The mice were divided into six groups.
Group I used as control were not given any treatment. Group II were given 0,2
mL of oleum olevarum (olive oil) orally to the end of the experiment. Group III
were induced to benzo (α) pyrene without being given any taurine. Group IV were
given 7,8 mg/bw of taurine before being induced to benzo (α) pyrene. Group V
were given 7,8 mg/bw of taurine after being induced to benzo (α) pyrene. Group
VI were given 15,6 mg/bw of taurine after being induced to benzo (α) pyrene.
Mice of group III, V, and VI were injected with 0,5 mL of benzo (α) pyrene solution
every day for 10 days on their subcutant tissue for the purpose of a nodule
being formed in this area. It was then continued by giving taurine orally for
15 days. In the final treatment, mice blood was taken to count the leucocyte
cells and erythrocyte cells. The data were analyzed using ANOVA (Analysis of
Variance) then continued by calculating least significant difference at 5 per
cent level of significance. The results indicated that taurine had the ability
to reduce leucocyte cells into its normal quantity, and was able to increase
the number of erythrocyte cells of mice suffered from leukaemia back to normal.
Penulis: Agra Maysa, E. L.
Widiastuti, H Busman
Kode Jurnal: jppertaniandd160248