AKTIVITAS ANTIMITOTIK DARI EKSTRAK KARANG LUNAK GENUS SINULARIA
ABSTRACT: Soft coral genus
Sinularia be a sources of terpenoid compounds that show efficacy in vitro
cytotoxic test using cancer cell lines. The study looked at the morphological
changes that occur in fungal mycelial growth of Pyricularia oryzae, such as
curling effect indicating antimitotic activity. Four extracts of soft coral
genus Sinularia have been examination and this is an primary test to obtain
information about the soft coral genus Sinularia that used as sources of
compound antimitotic. This research was conducted in several stages, ie
extraction of bioactive substances, P. oryzae fungal culture test, and biological
testing antimitotic activity with a qualitative assessment methods. From the
examination the Sinularia 3 ethyl acetate fraction show the strongest
antimitotic activity (to concentration 1,5 µg/ml). Ethyl acetate fraction was
purified using column chromatography. From the examination show that fraction
of ethyl acetate 1 is the best fraction because still show curling effect on
concentration 0,7 µg/ml.
Penulis: Wendy Alexander Tanod,
dkk
Kode Jurnal: jpperikanandd150134
