Uji Efek Analgetik Infusa Daun Beluntas (Pluchea indica L.) Pada Mencit Jantan Galur Swiss
ABSTRACT: Beluntas leaves
(Pluchea indica L.) have been known as analgetic reducer. The study about this
research has been going on right now. The goal of this research is to study the
analgesic effect of beluntas (P. indica) leaf infused into male mice of swiss
strain. The method used is the stretching chemical stimuli using acetic acid as
an inducer of pain. Healthy male mice of Swiss strain were divided into five
groups, and each group consisted of 5 mice. Group I was given paracetamol at a
dose of 65 mg/kg of body weight, group II were given distilled water , the
group III-V were given beluntas leaf infuse in the variation of 10 %, 20 % and
40 %. Thirty minutes after test substance application, acetic acid of 100 mg/kg
of body weight were given intraperitoneally in all groups and stretching of mice
was observed every 5 minutes for 1 hour. The data was analyzed by using
normality test of Kolmogorov-Smirnov; the test of homogeneity of variance was
analyzed by ANOVA and post hoc tests were to differenciate the percentage
analgetic of every group. Statistical test showed normal distributed and
homogeneous data; there are significant differences of percentage analgesic
between paracetamol and beluntas leaf infuse of 10, 20, and 40 % (p < 0.05).
There was significant differences between infuse of beluntas leaves with
positive control (parasetamol) in mice.
Penulis: SRI S.
WAHYUNINGSIH DAN LINDA WIDYASTUTI
Kode Jurnal: jpbiologidd150616
