KINETIKA PERMEASI KLOTRIMAZOL DARI MATRIKS BASIS KRIM YANG MENGANDUNG VIRGIN COCONUT OIL (VCO)
ABSTRACT: A kinetic study on
the release of clotrimazole from a VCO containing creambase has been undertaken.
The in-vitro release of the drug was studied by using a modification diffusion
cell apparatus. Four formulations of clotrimazole cream were prepared, each
contained either VCO or paraffin liquidum in the cream base. The amount of
clotrimazole release were determined by UVspectrophotometer. Results showed
that release of clotrimazole from all formulations followed Higuchi kinetics,
the release rate constant from F1 (containing VCO) was significantly differentthan
that from F1’ (containing paraffin liquidum) (p < 0.05). The rate constant
of clotrimazole from F2 (containing VCO); F2’ (containing paraffin liquidum )
and F1 were not significantly different.Virgin coconut oil (VCO) was a
potential cream base matrix regarding the release profile of clotrimazole from
the matrix.
Penulis: Henny Lucida, Patihul
Husni dan Vinny Hosiana
Kode Jurnal: jpkimiadd080161
