KARAKTERISASI FISIKOKIMIA DAN LAJU DISOLUSI DISPERSI PADAT IBUPROFEN DENGAN PEMBAWA POLIETILENGLIKOL 6000
Abstract: Solid dispersions of
the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG 6000) were
prepared by the melting method in order to increase the dissolution rates of
this poorly water-soluble compound. The temperature/composition phase diagram
of binary system was analyzed by termal analysis hot-stage microscopy, showing
an eutectic formation. Polarized light hot stage microscopy and X-ray-powder
diffraction confirmed, that solid dispersion technique decrease the crystalliny
of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofen
and polyethylene glycol 6000 respectively, which the results enhanced
dissolution rates compared to the physical mixtures and ibuprofen intact.
However, no such chemical interactions in the solid state were confirmed by
FTIR spectra which showed the presence of ibuprofen crystalline in solid
dispersion.
Kode Jurnal: jpkimiadd100188
