EKSTRAK SECANG SEBAGAI BAHAN DIURETIKUM (PERCOBAAN TERHADAP TIKUS PUTIH JANTAN GALUR SPRAQUE DAWLEY)
ABSTRACT: Empirically, secang
(Caesalpinia sappan L.) utilized as natural materials to overcome various types
of disease but not yet known how the influence of consuming secang against the
volume urine. The experiment was conducted on white male rats varian Spraque
dawley and sample test extract ethanol 96% of dried bark secang. The animal try
grouped in seven groups and each group consists of six animal try, namely
normal group, positive group (furosemide 10 mg/200 g BW), negative group (water
2 ml/200 g BW), Group of I dose (62,5 mg/kg BW), dosage II (125 mg/kg BW),
dosage III (250 mg/kg BW), and dosage IV (500 mg/kg BW). Thirty minutes after
granting test sample, the animal try given drinking water 2 ml/200 g BW by
gastric sonde, then put them in metabolite cages for 16 hours (overnight). The
result of experiment conducted show the average volume urine of animal try of
normaly group was 4,5 ml, negative group was 4,25 ml, dosage I was 4,5 ml,
dosage II was 8 ml, Dosage III was 5,75 ml and dosage IV was 5,5 ml. The volume
of animal try urine in the group II was the highest, so it can be said that
secang extract (dosage II – 125 mg/kg BW) can be used as diureticum material.
Penulis: Pertamawati, Nuralih
Nuralih, Fahri Fahrudin
Kode Jurnal: jpbiologidd141022
