EFEK PEMBERIAN VITAMIN E TERHADAP PENURUNAN KADAR MALONDIALDEHID (MDA) HATI MENCIT STRAIN JEPANG AKIBAT PAPARAN MINYAK GORENG BERULANG
ABSTRACT: SOR (Reactive Oxygen
Species) is a collection of free radical compound or compounds that easily
become free radicals and can damage the cell membrane is marked by elevated
levels of MDA (11) This is called oxidative stress, which can be prevented and
reduced by adequate intake of antioxidants into the body optimally. Oxidative
stress effects can be prevented by antioxidant vitamins, especially vitamin E.
The results of research show that the average value of mouse liver MDA levels
of the control group (A) 1.78 nmol/mL. The treatment group with repeated
delivery of cooking oil (B) have increased the average value of mouse liver MDA
levels (2.97 nmol/mL, 3.18 nmol/mL, 3.49 nmol/mL, 3.83 nmol/mL). In the
treatment group with doses of vitamin E 52 IU/Kg/Hr and repeat cooking oil (C)
have decreased the average value of mouse liver MDA levels (2.03 nmol/mL, 2.10 nmol/mL,
2.24 nmol/mL, 2.70 nmol/mL), compared with the provision of cooking oil over
it. We can conclude that there are differences in average MDA levels of the
liver of mice a significant between group A, group B1, C1 group (p = 0.003).
Mice liver MDA content significantly between group A, group B2, C2 group (p =
0.000), between group A, group B3, C3 group (0.001), between group A, group B4,
C4 group (0.000) where p <0.05.
Penulis: Elmatris Sy, Yustini
Alioes, Almurdi
Kode Jurnal: jpkimiadd100186
