Pertumbuhan dan Perkembangan Otak Fetus Mencit Setelah Induksi Ochratoxin A Selama Periode Organogenesis
ABSTRACT: This experiment
was performed to
examine the effects
of Ochratoxin A
(OTA) during organogenesis period on fetuses brain growth
and development. Thirty pregnant mice were divided randomly into 5 groups of
6. Ochratoxin A was dissolved in sodium
bicarbonate and administered orally on seventh to fourteenth days
of gestation at
dosage of 0.5,
1.0, 1.5 mg/kg bw,
respectively. The remaining animals were used as an untreated
control, and placebo were given by Sodium Bicarbonate. At the age of
18-day pregnancy, mice
were sacrified dan
taken its brains.
The fetuses brain
growth and development were observed
by measure brain
weight, cereberum width
and length, cerebellum
width and length, and the wall thichkness of cerebrum.
Result of this studies indicated that OTA caused decreased of brain weight, the
length and width of cerebrum and cerebellum, the wall thickness of cerebrum
significantly.
Penulis: ARUM SETIAWAN, MAMMED
SAGI, WIDYA ASMARA, DAN ISTRIYATI
Kode Jurnal: jpbiologidd130645
