Analisis Pertumbuhan Kartilago Epifisialis Os Tibia Fetus Mencit (Mus musculus L.) Swiss Webster Setelah Induksi Ochratoxin A Selama Periode Organogenesis
Abstract: The aims of this
study were determined the effects of Ochratoxin A (OTA) on growth of fetus
tibia epiphyseal cartilage during organogenesis period. Twenty four pregnant
mice were divided randomly into 4 groups of 6. Ochratoxin A was dissolved in
sodium bicarbonateand administered orally on seventh to fourteenth days of
gestation at dosage of 0.5, 1.0, 1.5 mg/kg bw, respectively. The remaining were
used as control. The fetal tibia was taken after the 18 th day of pregnancy.
The growth of tibia epiphyseal cartilages were observed histologically using
Erlich’s Haematoxylin-Eosin Stain. The result of this study indicated that OTA
caused decreased thickness of the rest zone, proliferative zone, maturation
zone and calsification zone of the fetus tibial growth plate significantly.
Penulis: Arum Setiawan, Mammed
Sagi, Widya Ismara, Istriati
Kode Jurnal: jpbiologidd120398
