The impact of β-hCG on placental angiogenesis in pre-eclampsia
Abstract: Numerous factors,
such as VEGF and intra-placental oxygenation, can influence placental
angiogenic activity. Early in the normal gestation period, β-hCG enhance VEGF
activity to induce angiogenesis. The aims of this study were to identify the
correlation between β-hCG concentration in placental culture and placental
angiogenic activity in pre-eclampsia. Ten placenta samples from women with
pre-eclampsia and l0 from controls (normal pregnancy) were collected. All
subjects agreed to participate in this study and signed an informed consent
form. β-hCG concentration in supernatant of placental culture was measured by
Microparticle Enzyme Immunoassay (MEIA) and placental angiogenic activity was
measured by endothelial cell migration toward placental explant (score 0-4).
The results showed that the median score of placental angiogenic activity in
pre-eclampsia was significantly higher than in normal pregnancy (p<0.05).
Concentration of β-ahCG in pre-eclampsia was significantly higher than in
normal pregnancy (p<0.001). hCG concentration in placental culture was
positively correlated to placental angiogenic activity both in pre-eclampsia
(r=+0.50) and in normal pregnancy (r=+0.57). Althouglt the correlations were
weak, β-hCG is considered one of the factors that influence placental
angiogenic activity.
Author: Sri B. Subakir, Tri
Jauhari, Pramita Iriana, Minarma Siagian, Sutarmo Setiadji
Journal Code: jpkedokterangg050115
