The benefits of progesterone therapy in imminent abortion
Abstract: The causes of
imminent abortion are multi-factorial. The biggest causal factor is the low
level of serum progesterone level. The lowest critical level of serum
progesterone for survivability of pregnancy is 10 ng/ml. Eighty percent of
patients experiencing abortion showed that their progesterone level was < 10
ng/ml. Patients who realized that their pregnancy would experience hemorrhage
generally would suffer from depression. Stress was one of the factors
responsible for the occurence of abortion. Administration of natural
progesterone substitution (not
progestogen) accelerates the disappearance of uterine contractions, and
speeds up the stoppage of bleeding. In addition, progesterone has the effect of
anti-anxiety. Adminstration of oral progesterone would result in metabolism in
the intestine and liver, such that physiological level of serum progesterone
could not be reached, while administration of suppositoria progesterone would
result in physiological level of serum, such that it was effective to prevent
imminent abortion.
Author: A. Abadi, Ali Baziad,
Andon Hestiantoro
Journal Code: jpkedokterangg050145
