THE APPLICATION OF HYDROTROPES AS MEDIUM IN THE EXTRACTION OF ANDROGRAPHOLIDE
Abstract: Hydrotrope solutions
provide safe and effective media for the microwave assisted extraction of
andrographolide, the major bioactive chemical constituent of plant Andrographis
paniculata. Microwave assisted extraction of androgpaholide was carried out by
using hydrotropes, sodium benzoate and urea. The objective of this work were to
determine the Minimum Hydrotrope Concentration (MHC) and to determine the
effectiveness of each hydrotrope with respect to andrographolide at different
system powers. The microwave assisted extractions of andrographolide were
carried out at different concentration of hydrotropes (0.2-3M) and different
system powers (39.9 and 119.7 Watt). Twenty grams of Andrographis paniculata
dried powder were added to 200 ml of hydrotrope solutions and extracted in a
microwave extractor for 15 minutes. The research result showed that the
percentage of the microwave assisted extraction of andrographolide by using
sodium benzoate and urea were up to 10.9% and 1.05% respectively. The Minimum
Hydrotrope Concentration and the effectiveness of hydrotropes that was measured
in term of Setschenow constant (Ks) were reported for two hydrotropes used in
this study.
Author: Indah Hartati, Laeli
Kurniasari, Yance Anas, Nur Aniq
Journal Code: jpfarmasigg140038
