PERUBAHAN SELULER DAN MOLEKULER PADA NEFROPATI DIABETIK
Abstract: Diabetic nehropathy
is the most prevalent complication of diabetes mellitus. Hiperglycemia in
diabetes mellitus activates several pathways leading to PKC activation. This
activation then induce molecular changes involving many growth factors and
cytokines. Various growth factors and cytokines further induce extracellular
matrix accumulation and mesangial cell expansion leading to glomerular
hypertrophy and sclerosis. This changes affects renal function in filtering
albumin and further damage can cause abnormal renal function and lead to renal
failure.
Penulis: Evy Sulistyoningrum
Kode Jurnal: jpkesmasdd140355
