PENGGUNAAN SPAN 40 SEBAGAI PENYUSUN NIOSOM NATRIUM ASKORBIL FOSFAT DALAM SEDIAAN GEL TERHADAP PENETRASINYA SECARA IN VITRO
Abstract: Sodium ascorbyl
phosphate is a hydrophilic compound that is difficult to pass through the
stratum corneum. One of the efforts to increase the penetration of the drug
through the stratum corneum is to develop in niosome system. This research aims
to determine the optimal concentration of span 40 to improve the entrapment
efficiency of niosome sodium ascorbyl phosphate that formulated in gel and
determine the stability and penetration ability of gel formulas. Concentration
of span 40 varied into three formulas: F1 (100 µmol), F2 (150 µmol) and F3 (200
µmol). Gel formulation was made in two formulas used gel base viscolam MAC 10: G1
(sodium ascorbyl phosphate in niosome system) and G2 (sodium ascorbyl phosphate
without niosome system). The stability tests performed for 28 days includes
organoleptic, pH and determination of levels of sodium ascorbyl phosphate in
gel. Penetration test performed by in vitro test using shed snake skin
membrane. The result showed F1 formula has an optimum entrapment efficiency
were 99,13%±0,099%. G1 formula has the most stable for 28 days of storage than
G2 formula. The used of span 40 as niosome composer can be increased
penetration of sodium ascorbyl phosphate in gel formulation were 89,04%±0,006%.
Penulis: Veni Lestiawati
Kode Jurnal: jpfarmasidd150170
