Optimasi dan Formulasi Tablet Mengapung - Mucoadhesive Glimepirid dengan Kombinasi Polimer Karbopol dan HPMC K4M
Abstract: Glimepiride is one
of the preferred drug for the treatment of type II diabetes mellitus. Diabetes
can affect gastric emptying time. Incomplete absorption of drugs often result
in small bioavailability. Glimepiride was chosen as model drug because it has
incomplete absorbtion due to less gastric residence time. Tablet make by direct
compression using polymer carbopol, HPMC K4M and other additives. This study
used factorial design. Factors that are optimazed are carbopol and HPMC K4M and
responses used are floating lag time, floating duration time, mucoadhesive, dan
DE 720. tablet were evaluated for invitro release characteristic for 12 hours. Area
optimum obtained on the composition of the combination of Carbopol 69.20 to
70.60 mg and HPMC K4M 10.66 to 24.67 mg.
Penulis: Hery Diar Febryanto,
Lusia Oktora Ruma Kumala Sari, Eka Deddy Irawan
Kode Jurnal: jpkesmasdd140361
