METABOLIC RISK FACTORS OF URINARY STONE DISEASE IN CHILDREN
ABSTRACT: To evaluate
metabolic risk factor of urinary stone disease in children. Material &
method: In this hospital-based preliminary
study, children with
urinary stone disease
who underwent stone
removal in Hasan
Sadikin Hospital were included. Control group consisted
children with other diseases, matched for age and BMI. Blood evaluation (uric
acid, calcium and phosphate) and 24-hour urine evaluation (calcium, phosphate,
sodium, magnesium, uric acid, acidity, and urine volume)
were measured before
the stone removal.
Stone analysis was
performed later. Data
was analyzed using Kruskal Wallis and Spearman correlation
test. Results: Eight subjects with urinary tract stone and 8 normal subjects
were included to the study. This study included 4 (50%) subjects with renal
stone, 3 (37,5%) subjects with bladder stone, and 1 (12,5%) subject with distal
urethral stone. Stone analysis revealed 6 (75%) calcium oxalate, 1 (12,5%)
calcium phosphate, and 1 (12,5%) struvite stone. There was no significant
difference in blood calcium, phosphate, and uric acid between groups. 24 hours
urinary calcium level was higher in subjects with stone disease (40,8 mg vs
10,6 mg, p=0,027). Urinary calcium-to-creatinine ratio was also higher in stone
disease (0,23 vs 0,02 mg/mg creatinine, p=0,002). There was no significant difference
of other urinary electrolites and uric acid level between groups. Conclusion:
Twenty four hours urinary calcium level and urinary calcium-to-creatinine ratio
is higher in children with urinary stone disease.
Author: Dandy Tanuwidjaja,
Safendra Siregar
Journal Code: jpkedokterangg120139
