EVALUATION OF IMMUNOMODULATORY ACTIVITY OF SESBANIA GRANDIFLORA FLOWERS EXTRACT IN MICE
Abstract: The aim of the
present study was to investigate the immunomodulatory activity of Sesbania
grandiflora on cellular and humoral immunity. Oral administration of the
methanolic extract (200 and 400mg/kg) of S. grandiflora flowers, in mice,
dose-dependently significantly enhanced the production of circulating antibody
titre in mice in response to SRBC. It significantly potentiated the
delayed-type hypersensitivity reaction induced by sheep red blood cells (SRBC).
Good response was also found towards phagocytosis in carbon clearance assay and
prevented myelosuppression in cyclophosphamide drug. Aqueous extract at
250mg/kg dose level failed to show immunomodulatory activity but 500mg/kg of
aqueous extract potentiated the activity
however less significantly compared with both dose of methanolic
extract. The results obtained in this study indicate that methanolic extract
(400mg/kg) of S. grandiflora possesses potential immunomodulatory activity.
Keywords: Immunomodulator, Sesbania
grandiflora, Humoral immune responses, Delayed type
hypersensitivity reaction, Phagocytosis
Author: Mallik Arunabha, Nayak
Satish
Journal Code: jpfarmasigg140040
