Analysis of sulfamethazine fates: an animal experimental with limited N-acetyltransferase as a models
ABSTRACT: Sulfamethazine has
been reported to destroy in vivo infection caused by positives and negative
gram microorganism. The objective of this study was to analyze the absorption,
distribution, metabolism and excretion of sulfamethazine in subjects with
limited N-acetyltransferase (mixed breed species and original breed species). We
determined the kinetics parameter of ten mixed breed subjects and ten original
breed subjects. The mixed breed subjects were used Bali mixed breed dogs and
the original breed subjects were used German shepherd dogs. The absorption,
distribution, metabolism and excretion kinetics and metabolic phenotypes of
subjects with mixed breed condition were determined by spectrophotometer UV-Vis
at 545 nm wave length and compared with original breed dogs. The result research
showed that several of kinetic parameters between two species of breed dog were
similar at p>0.05. The incidence of the poor metabolizer genotype between
two species of dog was similar (p>0.05). The absorption, distribution,
metabolism and excretion profiles of sulfamethazine between two species dog of
limited N-acetyltransferase (original dog and mixed breed) were similar.
Author: Mochamad Lazuardia
Journal Code: jpkedokterangg060002
