Identifikasi Keragaman Genetik Gen Reseptor Hormon Pertumbuhan (GHR|Alu I) pada Sapi Bali
Abstract: Growth
hormone receptor (GHR) is one factor affecting animal growth. GHR is required
by growth hormone (GH) to carry out its effects on target tissues. The
objective of the study was to estimate genetic diversity of the GHR|AluI gene
in bali, limousin, simmental and pesisir cattle. Genotyping was performed on
248 animals, including 162 bali, 21 limousin, 17 simmental and 48 pesisir.
Single nucleotide polymorphisms (SNP) had been found in exon 10, coding for the
cytoplasmic domain of GHR, which was located at position 81 bp (A/G) induced
amino acid substitutions Ser/Gly. Genotype frequencies of bali cattle AA (0.988),
GG (0.006) and AG (0.006) were evidenced for the GHR AluI monomorphism, but
mostly different from limousin GG (0.667), AA (0.238) and AG (0.095), simmental
AG (0.529), GG (0.471) and AA (0.000), pesisir AA (0.604), GG (0.375) and AG
(0.021) were the evidence of polymorphism. Homozigosity (monomorphism) in bali
cattle might be affected by adaptability in extreme environmental conditions
such as poor nutrition and improper management practices. It also could be
affected by natural selection and phenotype plasticity phenomena.
Penulis: Zulkharnaim, Zakaria,
R R Noor
Kode Jurnal: jppeternakandd100167
