THE EFFECT OF CONCENTRATION OF CARRIER, pH AND TIME OF EXTRACTION ON SEPARATION'S FACTOR OF PENICILLIN G - PHENYL ACETATE BY REACTIVE EXTRACTION
ABSTRACT: The aim of this
research is to study the effect of
concentration carrier, pH and time of extraction on separation's factor of
penicillin g - phenyl acetate by reactive extraction technique. The 10 mL aqueous
solution with variation of pH :
5, 6 contains 0.001 M penicillin G and 0.001 M phenyl acetate has been
extracted with 10 mL n-butyl acetate contains dioctylamine as carrier.
Variation concentration of carrier were
0.000; 0.002; 0.004; 0.006 and 0.008 M. Variation time of extraction were 1, 5,
10, 15 and 20 min. The penicillin G and
phenyl acetate that dissolved in organic phase ha been reextracted with 10 mL aqueous with variation of pH : 7, 8. The
optimum condition obtained as follow : concentration dioctylamine was 0.002M ;
pH the first phase water was 5 and the second phase water was 8 ; and the time
of extraction was 10 min.
Author: Imam Santoso, Buchari,
M.Bachri Amran, and Aminudin Sulaeman
Journal Code: jpkimiagg070017
