Sintesis Dan Prediksi Parameter Fisikokimia Senyawa Baru Berpotensi Anti-Inflamasi: Diasetil Pentagamavunon-1
ABSTRACT: Synthesis and
physicochemistry properties prediction of a potential anti-inflammatory agent,
diacetyl pentagamavunon-1 (diacetyl PGV-1), has been done. The synthesis was
using pentagamavunon-1 (PGV-1) (2,87x10-3 mole) and anhydride acetic acid
(26x10-3 mole; 37x10-3 mole; 49x10-3 mole) as starting materials and NaOH
ethanolic as a catalyst. The AM1 semiempirical quantum-chemical calculations
using the computational chemistry approach was used to predict and compare the
physicochemisty properties of diacetyl PGV-1 to PGV-1. Odorless, light-yellow
powder has been obtained. The powder was 0.8512-0.9602 g (2.02 x10-3 -
2.22x10-3 mole; 70.4-77.4%) and the purity of the powder was 92.4%. The purity
of the product has been examined by high performance liquid chromatography
(HPLC), while the structure elucidation has been done using IR (Infra Red),
1H-NMR (Nuclear Magnetic Resonance) and MS (Mass Spectroscopy). The
physicochemisty properties prediction showed that diacetyl PGV-1 was more
hydrophobic than PGV-1.
Penulis: Supardjan A. Margono,
Pudjono Pudjono, St. Layli Prasojo, Jeffry Julianus, Enade Perdana Istyastono
Kode Jurnal: jpkimiadd060058
