Sintesis 1,3-Dimetil-6,7-dimetoksi-3,4-dihidro Isoquinolina dari Metileugenol: Penerapan Reaksi Ritter dalam Siklisasi secara Langsung
ABSTRACT: The synthesis of
1,3-dimethyl-6,7-dimethoxy-3,4-dihydroisoquinoline from methyleugenol with
application of Ritter reaction for directly cyclization was presented. This research
was carried out in 2 steps : (1) Determination of intermediate stability that
undergo in the reaction by using hyperchem version 6 with AM 1 semi empirical
method, and (2) Synthesis of dihydroisoquinoline from methyleugenol and
acetonitrile with acid catalyst (H2SO4) in the laboratory. The result of AM 1
calculation found that generally, the intermediate encourage the formation
dihydroisoquinoline product, had low energy were compared with the intermediate
in other product. Therefore, the dihydroisoquinoline product was easily formed.
The result of experimental laboratory found that dihydroisoquinoline could be
synthesed from methyleugenol and acetonitrile in the presence sulphuric acid
under reflux in 74,92% yields. In despite, the minor product was formed with
amount 6,74%. While the reaction at room temperature gave dihydroisoquinoline
in poor yield about 11,42%.
Penulis: M. Farid Rahman,
Elvina Dhiaul Iftitah
Kode Jurnal: jpkimiadd060076
