Reactions of The First Cisplatin Hydrolytes cis-[PtCl( 15 NH 3 ) 2 (H 2 O)] + with N-Acetylcysteine
Abstract: The interactions
between cis-[PtCl( 15 NH 3 ) 2 (H 2 O)] + and N-acetylcysteine (H 3 accys) in
aqueous solution was investigated. In this reaction, polymeric solid was not
formed and the amine liberation was slower than that of cis-[Pt( 15 NH 3 ) 2 (H
2 O) 2 ] 2+ . Initially, the only product observed in the reaction of
cis-[PtCl( 15 NH 3 ) 2 (H 2 O)] + with a variety of thiols was a platinum(II)
species with chloride and the thiolate ligand bound monodentate through
sulphur, although different final product was obtained in each reaction. In
this reaction, after the formation of a species with thiolate bound monodentate
cis-[PtCl( 15 NH 3 ) 2 (H 2 accys-S), two new platinum products were observed,
namely a four-membered ring dinuclear platinum(II) complex, cis-[{Pt( 15 NH 3 )
2 ) 2 } 2 ( µ -Cl) ( µ -H 2 accys-S)] 2+ and a six-membered -S,O- chelate ring complex,
cis-[Pt( 15 NH 3 ) 2 (Haccys-S,O), while dinuclear sulphur-bridged complex
cis-[{Pt(NH 3 ) 2 } 2 (H 2 accys- µ -S) 2 )] 2+ , giving a broad peak in 15 N NMR, was only present in very tiny
amounts in this reaction.
Author: Sutopo Hadi
Journal Code: jpkimiagg060007
