Optimasi Waktu Reaksi dan Konsentrasi Ion Hidroksida Pada Sintesis Flavonoid Menggunakan Benzaldehida dan Turunannya
ABSTRACT: The aim of this
research is to determine the optimum time of reaction and concentration of
hydroxide ion on chalcone, 4-methoxychalcone and 3,4-dimethoxychalcone
synthesis. Chalcone and its derivatives were synthesized by dissolving KOH in
ethanol followed by dropwise addition of acetophenone and benzaldehyde. Then,
the mixture was stirred for several hours. Three benzaldehydes has been used,
i.e : benzaldehyde, p-anysaldehyde and veratraldehyde. The time of reaction was
varied for, 12, 18, 24, 30 and 36 hours. Furthermore, on the optimum reaction
time for each benzaldehyde the hydroxyl ion concentration was varied from
5,7,9,11 and 13%(w/v). The results of this research suggested that the optimum
time of chalchone synthesis was 12 hours, while, 4-methoxychalcone and
3,4-dimethoxychalcone were 30 hours. The optimum concentration of hydroxide ion
of chalcone synthesis was 13% and for 4-methoxychalcone and
3,4-dimethoxychalcone were 11%.
Penulis: Sri Handayani, Sunarto,
Susila Kristianingrum
Kode Jurnal: jpkimiadd050034
