Uji Efek Analgesik Ekstrak Etanol Mencit Jantan dengan Metode Tail-Flick
Abstract: In the previous
study the analgesic effect of Cinnamommum zeylanicum Breyn had been investigating.
The aim of this study was to investigate analgesic effect of the 70% ethanol extract
of cinnamon bark (Cinnamommum zeylanicum Breyn.). This study used Tail- Flick
method at 25 male mice which have passed sensitivity test, divided into five
groupes. Group I as negative control was administered 0,5% CMC, group Il as
positive control was administered tramadol HCI, group Ill, IV and V was
administered extract of cinnamon bark at 8; 16 and 32 mg/20 g BW. Drugs were
orally administered to mice. The reaction of time exhibited by each animal was
counted for two hour with interval thirty minutes. The Result revealed that the
prepared extract in at the all dose, had analgesic effect significantly in all
groups which have been studied (p< 0,05) in comparison to the negative
control, to the highest analgesic effect by dose (32 mg/ 20 g BW). Our results
showed that the analgesic effect of extract (32 mg/20 g BW) the same with
tramadol hidroclorida.
Penulis: Widiarti
Kode Jurnal: jpfarmasidd120145
