PENGARUH SEDIAAN GEL EKSTRAK BUAH TOMAT (Lycopersicum esculentum Mill) TERHADAP WAKTU PENYEMBUHAN LUKA PADA TIKUS GALUR WISTAR SEBAGAI HEWAN MODEL DIABETES MELITUS
Abstract: Diabetes mellitus is
a chronic disease that is characterized by blood glucose levels exceed to
normal range and cause various complications; one is ulcer/diabetic wound. Chronic
wounds in patients with diabetes mellitus are caused by oxidative stress due to
the increased production of free radicals. One of the free radicals are ROS
(Reactive Oxygen Species) that will increase which causes prolonged
inflammatory phase of wound healing then the time of wound healing will also be
elongated. It needs fairly powerful antioxidants; one of them is a carotene
lycopene which gives the red color in tomatoes. Therefore, we need a research
to determine the effect of tomatoes towards the time of wound healing that are
tested in the preparation of gel. The preparation of gel can retain moisture as
it supports wound epithelization. True experimental study with randomized
design (simple randomized designed) was conducted in the Laboratory of Pharmacology
Faculty of Medicine, Udayana University. The result shows there is significant
effect of gel preparation of tomato fruit extracts towards the time of wound
healing with the results of One-Way ANOVA test showed p = 0.000 (p < 0.05)
which means that H0 is rejected. The time of wound healing with treatment of
gel with tomato extract is the shortest time of wound healing between the
animal model of diabetes mellitus that is an average of 12.17 days (with
placebo gel on average of 13.83 days, with a wet gauze bandage NaCl 0.9% on
average of 20.00 days) and the group that was not induced by alloxan recovered
an average of 8.00 days. For further research, this study is expected to
proceed to a higher level so that the gel preparation of tomato fruit extract
can be used as an alternative natural-based modern wound care in the management
of diabetic wounds.
Penulis: Carolina, AI., I Made
Mertha, S. Kp, M. Kep., Ns. I Kadek Saputra, S.Kep
Kode Jurnal: jpkeperawatandd150025
