Pengaruh Pemberian Sari Buah Mengkudu (Morinda citrifolia Linn.) Terhadap Glibenklamid dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes
Abstract: Drug interactions
can occur in the use of two or more drugs simultaneously, including the use of
synthetic drug with herbal medicine. Combination of glibenclamide with noni juice (Morinda
citrifolia Linn.) often used by diabetic
patient to decrease their blood glucose level. lhe aim of this research
was to know the interaction between
glibenclamide and noni juice administration on blood glucose level. This research used 24 Sprague-Dawley
male rats which were divided into 6 groups. Before the experiment, the rats
were first induced by alloxan, except group 1, which was the normal control.
Group 2 was the control of diabetic without given any drugs. Group 3 and 4 were
the control of glibenclamide (0.9 mg/200g body weight of rat) and of noni juice
(2.5 ml/200g body weight of rat) respectively. Group 5 and 6 were the
interaction test group which were given glibenclamide (0.9 mg/ 200 g body
weight rat) and noni juice (2.5 ml or 5.0 ml/200 g body weight of rat) with an
hour interval. The blood glucose level was measured by using spectrophotometer
with o-toluidine as reagent. The result of this research shows that noni juice
at a dose 5.0 ml/200 g body weight rat was able to increased the reduction of
blood glucose levels by glibenclamide after two weeks administration.
Penulis: Santi Purna Sari
Kode Jurnal: jpfarmasidd120141
