PENGARUH PEMBERIAN EKSTRAK KERING DAUN SUKUN (ARTOCARPUS ALTILIS) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS PUTIH DIABETES MELITUS
Abstract: Breadfruit leaf is a
natural material (herb) which can be used as an anti-hyperglycemic drug. One of
the compounds in breadfruit leaf that can decrease blood glucose level is
Quercetin. A variety of polar solvents can be used to activate this compound in
breadfruit leaf, such as water, ethanol
and methanol. The use of ethanol, even more selective and have positive role
when separating flavonoid in breadfruit leaf, but ethanol extract in liquid or
viscous form also has some weaknesses, wherein the extract can not be stored
for a long time and easily damaged because of water medium in the extract is an
ideal and great place for fungus to multiply. Based on these facts, it is
necessary to create a new method in processing breadfruit leaf extract to
obtain better results than the previous, by using dry extract. This study aims
to determine the effect of dry extract of breadfruit leaf (Artocarpus altilis)
on blood glucose level in mice with diabetes mellitus. This research is a true
experimental with a completely randomized design. The treatment group is
administration of breadfruit leaf dry extract at a dose of 135 mg, 270 mg, 405
mg and 1 negative control group which have no intervention. Normality test
using Shapiro-Wilk and data was analyzed with One Way Anova test and show
significant differences (p: 0.000 <? 0:05). The results of analysis with
post hoc tests show significant differences between treatment groups dose 1
with dose 2 (p <0.05). The conclusions of this study are breadfruit leaf dry
extract have some effects on blood glucose level of mice with diabetes
mellitus, and there are significant differences in blood glucose levels between
treatment groups which have given breadfruit leaf dry extract dose 2 with dose
3.
Penulis: Gusti Bagus Jelantik
Darma Putra
Kode Jurnal: jpkeperawatandd140187
