PENGARUH EKSTRAK ETANOL DAGING BEKICOT (Achantina fulica) TERHADAP KADAR KOLESTEROL TOTAL, HDL, DAN LDL SERUM DARAH TIKUS JANTAN GALUR WISTAR
ABSTRACT: Cholesterol was
a steroidal compounds
contained in the
human body. Cholesterol imbalance in the body caused
hypercholesterol disease. Acharan sulfate is a compound found in snail body and
potentially lowering cholesterol level. Acharan sulfate was extracted from snail body
with maceration method
using ethanol solvents.
Research was done
by using animals model, male rats
(Rattus norwegicus) Wistar strain which was two months old and weighing 180 to
200 grams. The animals model were divided into six groups. One groups used as
normal control. Five groups were treated with high cholesterol diet with
suspense of cow fat and yellow egg for ten days. After that, three groups were
treated with the ethanolic extract of snail body with doses of 40 mg/kgbw, 80
mg/kgbw, and 160 mg/kgbw. The two other groups were treated with Simvastatin
and BR II feed (disease control). Total cholesterol, HDL and LDL concentrations
were determined using enzymatic photometric test CHOD-PAP method. Results showed
that snail body the ethenolic extract of decreased total cholesterol concentration
by 6,33 mg/dl at doses 160 mg/kgbw and 4,90 mg/dl at doses 80 mg/kgbw. HDL
concentration increased by 0,85 and 8,06 mg/dl respectively at doses 80 mg/kgbw
and 160 mg/kgbw. LDL
concentration decreased by
1.96 mg/dl, 2.22
mg/dl and 3.52
mg/dl respectively at doses 40, 80, and 160 mg/kgbw.
Penulis: Wahyu Widyaningsih,
Aditya Prabowo, Sumiasih
Kode Jurnal: jpfarmasidd100032
