FORMULASI GRANUL MUKOADHESIF DISPERSI PADAT KETOPROFEN–PVP K-30 MENGGUNAKAN KITOSAN
Abstrak: A study on
mucoadhesive properties of ketoprofen – PVP K-30 solid dispersion granules
using chitosan had been done. Solid dispersion of ketoprofen and PVP K-30 was
made at ratio 1:1 using solvent method. Granules were made by wet granulation
method at various concentrations of chitosan (10%, 20% and 30%). The granules
were evaluated including photomicroscopy, flow rate, angle slides, water
content, particle size distribution, dissolution test, in-vitro test bioadhesif
and wash off test. The release of ketoprofen from the granules was determined
using basket dissolution test in pH 7.5 phosphate buffer medium for 8 hours.
Mucoadhesive properties were tested by in-vitro bioadhesif tests and wash off
test. The dissolution test showed the dissolution effeciency value of formula
1, 2, and 3, respectively, was 78.9890 ± 1.1398; 77.3889 ± 1.4312, and 75.8869
± 0.2210 %. Results showed a decrease in the release of the active substance
from the granules, with the increase in chitosan concentration. Statistical
analysis of the efficiency of dissolution showed a significant difference among
the three formulas with (P <0.05). In vitro bioadhesif tests showed that
granules were able to attached to the stomach and intestinal mucosa of rabbits.
Penulis: Salman, Meryza, Deni
Noviza
Kode Jurnal: jpfarmasidd130022
