EFEK EKSTRAK BAWANG MERAH ( Allium ascalonicum L.) TERHADAP PERUBAHAN SUHU TUBUH PADA TIKUS PUTIH (Rattus norvegicus) YANG MENGALAMI DEMAM
Abstract: Red onion is one of
multipurpose herb. Onion bulbs contain nutrients and non-nutritional substances
(phytochemicals). Phytochemical compounds found in onion one is flavonoids.
Flavonoid compounds has been known that have anti-inflammatory effects and has
also worked as an antipyretic effects of inhibitors of cyclooxygenase (COX),
which Has function to trigger the formation of prostaglandins. Prostaglandins
play a role in the inflammatory process and increased body temperature. When
prostaglandins are not inhibited, the body temperature increases that would
result in fever. This study aimed to determine the effect of onion extract
(Allium ascalonicum L.) towards the changes in body temperature in white
rats (Rattus norvegicus) who experience
fevers. This research is true experimental research with pretest and posttest
with control group design. Twenty-eight white male rats aged 2-4 months is
induced by DPT vaccine (0.5 cc intraperitoneal), and then divided into 4
groups. Group I (onion extract dose 126mg/100 g BB), group II (onion extract
dose 252mg/100gr BB), group III (onion extract dose 378mg/100 g BB), group IV
(distilled water) as a negative control. Temperature measurements carried out
at the first before induction, 1 hour after induction and every 30 minutes
until 120 minutes after treatment. Results were analyzed by ANOVA test followed
by post hoc test. The conclusion of this study is that there is the effect of
extracts of onion (Allium ascalonicum L.) to changes in body temperature of
rats (Rattus norvegicus) with fever.
Penulis: Wiryawan, I Gede
Agus., Ns. A.A. Istri Putra Kusumawati, S.Kep, M.Ng, Ns. I Putu Artawan S.Kep
Kode Jurnal: jpkeperawatandd150015
