Uji Bioaktivitas Ekstrak Etil Asetat Kulit Manggis (Garcinia mangostana L.) sebagai Antidiabetes pada Mencit Putih (Mus musculus L.) Jantan
Abstract: Diabetes mellitus
represents a disease marked with blood glucose level that exceeding situation
of normal boundary ( hiperglikemia). Treatment of this disease can be done with
medicall and alternativety. Medication of alternativety by using materials of
flora owning effect of hipoglikemia like ethyl acetate extract of mangosteen
rind (Garcinia mangostana L.). This study about activity determination of
antidiabetes ethyl acetate extract of mangosteen rind. This study to know
influence giving of ethyl acetate extract mangosteen rind to degradation of
blood glucose level of the white male mice (Mus musculus L.), and to determine
effective treatment time and dose to blood glucose level of the white male
mice. Glucose blood levels determined with glucose tolerance method use
appliance of NESCO Multicheck Glucose®. Dose variation ethyl acetate extract of
mangosteen rind the used 125, 250 and 500 mg/kg BW with time variation of 60,
90, 120, and 150 minutes. The decreasing blood glucose of analysed
statistically by using analysis of variant (ANOVA) and followed by Duncan’s
multiple reng test. The decreasing result of examination of KGD (blood glucose
level) with dose 125, 250 and 500 mg/kg BW give effect of blood glucose
levels meaning, where calculated F value
> critical F value. Price of calculated F value is 6,25, while critical F
value is 4,77 (0,01 α). Dose of ethyl acetate extract mangosteen rind that gives
the highest blood glucose level 20,4 % is 500 mg/kg BW with time a time of
ethyl acetate extracts of mangosteen rind 150 minutes.
Penulis: Sri Hastuti Siregar,
Iryani Iryani, Erda Sofjeni
Kode Jurnal: jpkimiadd130534
