Uji Bioaktivitas Antidiabetes Ekstrak Etil Asetat dari Kulit Buah Jengkol (Pitecellobium jiringa (Jack) Prain ex King) pada Mencit Putih (Mus musculus L) Jantan
Abstract: Diabetes mellitus is
a metabolic disease characterized by blood glucose level that exceed normal
limits (hyperglycemia). Treatment of this disease can be done with medicall and
herbs. Among the herbal treatment is to use plants such as pandanus pandan
wangi, sambiloto, rind mahkota dewa and rind jengkol (Pithecellobium jiringa
(Jack) Prain ex King) which has antidiabetic effect. We have done a research of antidiabetic bioactivity of ethyl acetate
extract from the rind jengkol on white male mice. The goal of research to
determine the effect of ethyl acetate extract of the rind jengkol in decreasing
blood glucose levels of the male white
mice (Mus musculus L.), and to determine the dose and timing of the ethyl
acetate extract in lowing blood glucose
level to the olwest point. Research was conducted with on experimental study
with a completely randomized design (CRD) with two factor variation is doses of
ethyl acetate extract (125, 250, and 500 mg / kg mice) and treatment time
(60,90,120, and 150 minutes). This study uses a glucose tolerance test. Blood
glucose level of mice were measured using a Glucose Multicheck NESCO ®. Data
were statistically analyzed using analysis of variants (ANOVA), followed by
Duncan's multiple reng test. The result showed that the ethyl acetate extract
of the rind jengkol on white male mice gives the effect on decreasing the mean
blood glucose level, which Fcalculated> Ftable. Fcalculated is 10.93, while
the F table is 4.77 (0.01 α). Dose of ethyl acetate extract rind jengkol that
gives the highest blood glucose level drop is 500 mg / kg with a treatment time
of ethyl acetate extract of rind jengkol 150 minutes.
Penulis: Elfi Yenti, Iryani
Iryani, Erda Sofjeni
Kode Jurnal: jpkimiadd130524
