Pengaruh Air Rendaman Rumput Fatimah (Anastatica Hierochuntica L) terhadap Frekuensi Kontraksi Uterus Tikus Galur Spragua Dawley pada Fase Estrus
Abstract: The frequency of
contraction is one of the mechanical activities of uterine smooth muscle
contractions. Recording was done without and with 0,01 IU oxytocin stimulation
entered into organ bath within uterine smooth muscle strips. The aim of this
research was to investigate the effect of water soaked of fatimah grass
(Anastatica hierochuntica L) on the frequencies of uterine smooth muscle
contractions of rattus norvegicus Sprague Dawley at the estrous phase both in
without and with 0,01 IU oxytocin stimulation
This research was laboratory experimental with post test only control
group design. The samples were 40 uterine smooth muscle strips rattus
norvegicus Sprague dawley 10-14 weeks, 150 – 250 gr weight, on the estrous
stages. The rats were divided into 5 groups. Control group was treatment by
vehicle of solution (water), equivalent group was treatment by estradiol, and
the others were treatment by fatimah’s grass 10 gr, 20 gr, and 40 gr that
soaked into 350 cc hot water (70oC) during 12 hours. Twenty hours after
treatment, rats were killed, and than uterine smooth muscle was removed and connected
to chymograph to record the contractions.
The data was analyzed by one-way Anova and the results showed that there
was no significant differences in frequencies between treatment groups and
control or equivalent groups on the uterine smooth muscle strips both in with
and without 0,01 IU oxytocin stimulation. And then paired t-test results showed
that there were significant differences between frequencies without and with
0,01 IU oxytocin stimulation at estradiol (p=0,032), RF10 (p=0.026), RF20 (p=0,001),
and RF40 (p=0,027) groups.
It could be concluded that water soaked of fatimah grass (Anastatica
hierochuntica L) could increased the frequencies of uterine smooth muscle
contractions of rattus norvegicus Sprague Dawley at the estrous phase.
Keywords: Fatimah’s grass
(Anastatica hierochuntica L), the quality of uterine smooth muscle contraction,
frequency , estrous stage, oxytocin, estrogen
Penulis: Desiyani Nani
Kode Jurnal: jpkeperawatandd090001
