Visual Acuity of Methanol Intoxicated Patiens Before and After Hemodialysis, Methylprednisolone and Prednisone Therapy
ABSTRACT: Methanol
intoxication is intoxication because of methanol comsumption causing
simmetrical optic neuropathy, metabolic acidosis and death. The mechanism of
methanol toxicity has closely been linked to the effect of formic acid from
methanol by alcohol dehydrogenase. The aim of this study is to investigate the
relationship of visual acuity in methanol intoxication before and after
hemodialysis, methylprednisolone and prednisone therapy. This study was a
retrospective descriptive study to sixteen subjects. Each subject was treated
with hemodialysis and methylprednisolone 1000 mg/day intravenous for three
days, continued with prednisone 1mg/kgbw/day for 11 days. Visual acuity and
optic nerve were observed on the first, second, third, and seventh day. The larger
proportion were males (94%). The mean age was 28.8 ± 8.7 years. The onset to
hospital was 29.2 ± 13.3 hours after methanol intoxication. Visual acuity at
the first hospitalized was 1.42 ± 0.36 logMAR on the right eye and 1.45 ± 0.37
logMAR on the left one and blood pH was 7.18 ± 0.06. Optic nerve was hyperemia.
Started from the second day of therapy, significant change on visual acuity was
on right (p = 0.004; p = 0.001, p = 0.001 Wilcoxon test ) and the left eye (p =
0.004; p = 0.002; p = 0.001; Wilcoxon test). No significant change in optic nerve
was found. A significant visual acuity improvement is found after hemodialysis,
methylprednisolone and prednisone therapy. The optic nerve is hiperemia, and
bilateral simetric.
Key words: Methanol intoxication;
toxic optic neuropathy; hemodialysis, methylprednisolone, prednisone
Penulis: AA Mas Putrawati Triningrat,
Ni Made Kartika Rahayu, IB Putra Manuaba
Kode Jurnal: jpkedokterandd100020
