Transduksi Sinyal Hormon Kolesistokinin sebagai Target untuk Mengatasi Obesitas
Abstract: In the last decade,
the number of overweight children and adults has increased all over the world.
In Indonesia, obesity needs
serious management because
it is multi-factorial etiology.
One of the predominant factors
of obesity is
excessive-appetite. This paper
aims to discuss
a gut hormone
called cholecystokinin
(CCK), which has
been proven to
be able to
decrease appetite. CCK
has a short
term anorectic effect, which becomes the reason for the hormone to be
one of therapeutic targets of obesity in the future. CCK
is produced in the enteroendocrine cell along the
small gut mucous
and the secretion
is stimulated by protein
and fat through
signal transduction mechanisms
called G Protein
Coupling Receptor (GPCR), GPR
93. Then they
activate Extracellular Signal-Related Kinase
(ERK) 1/2 through Gαq and Gαi signal transduction.
Soybean contains a bioactive protein, β-conglycinin (BconP) subunit–β, which has
been proven to
be the best
inducer for CCK
secretion. The well-known
signal transduction pathway is
Gαq-coupled GPCR, which
influences the calcium
signal and activates
Protein Kinase C (PKC). However, the downstream signaling to
complete the pathway remains unclear and further study will be needed to
explore the whole process.
Penulis: Meilinah Hidayat,
Muchtan Sujatno, Nugraha, Setiawan
Kode Jurnal: jpkedokterandd100049
