Pengaruh Pemberian Ekstrak Buah Mahkota Dewa Dosis Bertingkat Terhadap Proliferasi Limfosit Lien pada Mencit BALB/C
Abstract: Mahkota dewa (Phaleria papuana) fruits consists of
chemicals that are able to increase lymphocytes proliferation. The objective of
this study was to show the influence of Mahkota dewa's fruits extract in spleen
lymphocytes proliferation of BALB/C mice. An experimental study with the
post-test only control group design was carried out on experiment animal BALB/C
mice, consisted of 25 male mice which devided into 5 groups. K was control
group without treatment with mahkota dewa extract, whereas P1 was group treated
with mahkota dewa extract 0,2 ml/day (± 35 ìg extract). P2 was group given
mahkota dewa extract 0,4 ml/day (± 70 ìg extract), P3 was group given mahkota
dewa extract 0,8 ml/day (± 140 ìg extract), and P4 was group given mahkota dewa
extract 1,5 ml/day (± 280 ìg extract). Lymphocytes from the spleen of all mice
were isolated after 2 weeks treating. Lymphoblasts were counted in every 200
cells. There were significant differences in lymphoblasts count between K and
P1 (p=0,009), K and P2 (p=0,028), P1 and P2 (p=0,009), P1 and P3 (p=0,009), P1
and P4 (p=0,009), P2 and P3 (p=0,012), P2 and P4 (p=0,028). And there were no
significant differences in lymphoblasts count between K and P3 (p=0,917), K and
P4 (p=0,675), P3 and P4 (p=0,917). On
the giving of mahkota dewa's fruits extract there were significant increase of
lymphocyte proliferations on BALB/C mice on P1 and P2 groups. But there were
not on P3 and P4 ones.
Penulis: M. Saifulhaq M.
Kode Jurnal: jpkedokterandd090048
