Pemberian Kombinasi Vitamin C dan E Peroral Memperbaiki Kerusakan Hepar Akibat Paparan Rokok Kretek Sub Kronik
ABSTRACT: Free radicals in
cigarette smoke can destroy tissue and cells of the body. The activity of free
radicals can be reduced by antioxidants from external and internal. The
objective of this research is to investigate the effects of vitamin C and
vitamin E combination on the histopathology of rat liver exposed by subcronic
cigarettesmoke. This research using true experimental study with post test only
control group design. The sample of this research we used 32 Wistar rat, ages
between 2-3 months, weight 150-200 grams divided 8 grouped. Cigarette smoke
exposed for 10 weeks. Parameter will be measured is the number of liver cells
damage(necrosis). Data analysis uses the One-Way ANOVA method followed by
Turkey test. The result show the number of liver cells damage are significantly
decrease. The conclution vitamin C and vitamin E combination decrease the
number of the liver cells damage of the rat liver, that has been exposed to
subcronic cigarette smoke at optimal doze 0,20 mglg bw vitamin C and 0,04 lUlg
bw vitamin E.
Penulis:I Ketut Gede Muliartha
Endang Sriwahyuni , Yuliawati
Kode Jurnal: jpkedokterandd090138