Pemberian Kombinasi Vitamin C dan E Peroral Memperbaiki Kerusakan Hepar Akibat Paparan Rokok Kretek Sub Kronik

ABSTRACT: Free radicals in cigarette smoke can destroy tissue and cells of the body. The activity of free radicals can be reduced by antioxidants from external and internal. The objective of this research is to investigate the effects of vitamin C and vitamin E combination on the histopathology of rat liver exposed by subcronic cigarettesmoke. This research using true experimental study with post test only control group design. The sample of this research we used 32 Wistar rat, ages between 2-3 months, weight 150-200 grams divided 8 grouped. Cigarette smoke exposed for 10 weeks. Parameter will be measured is the number of liver cells damage(necrosis). Data analysis uses the One-Way ANOVA method followed by Turkey test. The result show the number of liver cells damage are significantly decrease. The conclution vitamin C and vitamin E combination decrease the number of the liver cells damage of the rat liver, that has been exposed to subcronic cigarette smoke at optimal doze 0,20 mglg bw vitamin C and 0,04 lUlg bw vitamin E.
Keywords: vitamin C, vitamin E, cigarette smoke, liver cells damage
Penulis:I Ketut Gede Muliartha Endang Sriwahyuni , Yuliawati
Kode Jurnal: jpkedokterandd090138

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