Karboksimetil Kitosan Menurunkan Degranulasi Mast Cell yang Diinduksi Oleh Ovalbumin
ABSTRACT: Ovalbumin is known
as mast cell degranulating agent through the FCεRI aggregation. Carboxymethyl chitosan
(CMCs), a biocompatible cationic polymer was evaluated to reduces mast cell
degranulation induced by ovalbumin. In this experiment, wistar rats were darboxymethyl
chitosan ivided into 5 groups which consist of 1 control group and 4 allergen
groups. Among the allergen groups, 3 groups were treated with carboxymethyl
chitosan/CMCs (doses : 0,25 mg, 0,50 mg and 1,00 mg) for 22 days. The result
showed a significant (P<0,01) reduction in mast cell degranulation in
allergen groups. This finding indicate that CMCs possesses antiinflammation activity
mediated by reducing of mast cell degranulation.
Penulis: Mohamad Nur Ibrahim,
Edi Widjajanto, Nur Permatasari, Akhmad Sabarudin
Kode Jurnal: jpkedokterandd090136
