Association Between Refractive Changes And Blood Glucose Changes In Diabetic Mellitus Type 2 Patient
Abstract: Purpose, To
evaluate association between
Refractive Changes and
Blood Glucose Changes
in Diabetic Mellitus Type 2 Patient.
Method: Twenty eyes
of patients with
diabetes mellitus type
2 were included
in this prospective study. During
the observation period,
patients underwent general
ophthalmological examination including
refractive measurement and blood glucose level at first admission then second
measurement was performed when patient controlled. Measurements at baseline and
during maximal hyperglycemia were analyzed.
Results: A refractive change occurred in all patients who had blood
glucose changes. The patient had DM
1 – 4
years (mean 2.5
years) and HbA1C
6.2 % -
7.53 % (mean
7.03 %). On
first admission refractive
measurement – 4.00 D until + 4.50 D (– 0.44 ± 2.51) and when controlled – 3.50
D until + 3.50 D (
– 0.39 ± 1.99). Blood
glucose concentration 105 – 361
mg/dL (186.73 ±
61.94) and when controlled 112 – 492 mg/dL (229.31 ±
92.41). Refractive changes was 4.00 D until 1.25 D (– 0.04 ± 1.46) and blood
glucose concentration changes was – 63 until 131 mg/dL (44.15 ± 48.49). There
was a negative correlation between refractive changes and blood glucose changes
(p< 0.05) and there were refractive changes – 1.007 D every 100 mg/dL blood
glucose changes.
Conclusion: There was a negative correlation between refractive changes
and blood glucose changes in
patient with diabetic
mellitus type 2.
This finding could
provide the refractive
changes that are often
observed in patient
with diabetic mellitus
also a reduction
of refractive index
in intraocular tissues,
especially in lens, appears to be responsible for this refractive change.
Penulis: Indri Wahyuni,
Soebagijo Adi, Rowena Ghazali Husein
Kode Jurnal: jpkedokterandd080008
