Sifat Anti Cendawan Trichophyton mentagrophytes dan Candida albicans dari Zat Ekstraktif Kayu Pelanjau (Pentaspadon motleyi)
Abstract: Pelanjau wood (P.
motleyi) extractives traditionally used as medicine for skin infection such as
scabies (tinea) and rash caused by fungal T. mentagrophytes and C. albicans.
The aim of this research was to identify the effectiveness of pelanjau wood
extractives on growth inhibitory of fungal T. mentagrophytes and C. albicans,
isolate and identify extract compounds which have antifungal properties.
Extraction and fractionation process yielded 7,04% of ethanol extract
consisting of 0,28%, 1,28%, 1,19% and 4,29% of n-hexane, diethyl ether, ethyl
acetate and residue fractions, respectively. Antifungal activity of pelanjau
wood extract more effective on C. albicans growth inhibition than T.
mentagrophytes fraction ethyl acetate at (0,03 and 0,06 mg/ml of MIC and MFC,
respectively). Isolation of ethyl acetate fraction was resulted dominant
compound EA6a and EA6c. NMR and GC MS analysis of compound EA6a indicate
2-Hidroxy octadecanoid acid, Hexadecanoic acid, Ethyl oleate, Octadecanoic
acid, Vanilin and phenol,2-methoxy-4-(1-propenyl) as the possibly main
component belonged to fatty acid and phenol group. Compound EA6c indicate
Phenol, 4-(1,1 dimetylpropyl), Nonylphenol isomer,
Phenol,4-(1,1,2,2-tetrametylbutyl), Nonyl-phenol mix isomer dan 4-Nonylphenol
as the possibly main component in belong to phenol group.
Key words: Extractives,
Pentaspadon motleyi Hook.f, antifungal, Trichophyton mentagrophytes, Candida
albicans
Penulis: Fathul Yusro, Wasrin
Syafii, Eko Sugeng Pribadi
Kode Jurnal: jpkehutanandd100006
