EFEK HIPOKOLESTEROLEMIK TEPUNG UMBI GADUNG (Dioscorea hispida Dennst)PADA TIKUS WISTAR JANTAN YANG DIBERI DIET HIPERKOLESTEROL
ABSTRACT: Yam tuber (Dioscorea
hispida Dennst) contains water soluble polysaccharides. Itis supposed that water soluble
polysaccharides from yam functions as bioactivecompound to decrease blood
cholesterol level. The hypocholesterolemic effect of watersoluble polysaccharides
in yam tuber (Dioscorea hispida Dennst) flour on Wistar rats(Rattus norvegicus)
lipid profile was investigated. A two
month old Wistar rats (Rattusnorvegicus) consisted of three groups (P0, P1 and
P2) with five rats of each group wereadapted for one week by giving standard
diet (AIN-93). P0 group was treated bystandard diet AIN-93M, P1 group was
treated by standard diet and force feeding by eggyolk as cholesterol source,
whereas P2 were given modified standard diet (AIN-93M withyam tuber flour). The
weight and cholesterol level were measured in 4 weeks. Bloodwas drawn from eyes
(retro orbital plexus) every week for analyzing cholesterol levels(total
cholesterol, HDL, LDL cholesterol and triglycerides). Research showed
thatstandard diet (AIN-93M) which is modified with yam tuber flour (P2) could
decrease totalcholesterol as much as 15.37 mg/dL, 18.85 mg/dL of total
triglycerides, and 14.24mg/dL of LDL-c level. Conversely this modified diet can
increase the HDL-c level asmuch as 27.20 mg/dL.
Keywords:
hypocholesterolaemic, yam tuber flour, lipid profile, hypercholesterol
diet,wistar rat
Penulis: Jaya Mahar Maligan,
Teti Estiasih, Wenny Bekti Sunarharum, Thomas Rianto
Kode Jurnal: jppertaniandd110012
