ABSTRACT: Phytoestrogen is the
chemical compound contains in plant which has estro-genic like effect. Estrogen
has important function on woman’s sexual organ, such as proliferation of
uterine and vaginal cornification. Phytoestrogen are weak agonists for estrogen
and illicit statistic significantly increases in uterine wet weight, at definite
dose, in uterothrophic bioassay. Biji Klabet or Fenugreek seed (Trigonella foenum-graecum
L.) contains steroidal sapogenins such as diosgenin, tigogenin, gitogenin,
yamogenin and trigoneoside, that suspected having an estrogen-like ef-fect or
as phytoestrogen. The aim of this research was to investigate the estrogenic effect
of fenugreek’s ethanolic extract in ovariectomized and immature rats models. These
models represent the climacteric/menopause phase, where estrogen level is very
low because ovary produces no estrogen. The testing animals were divided into normal
group, ovariectomized control group, estradiol control group and three level doses
of fenugreek extract (30mg/200gBW; 60mg/200gBW and 120mg/200gBW). The result
indicated that start on 60mg/200gBW, fenugreek extract significantly could
increasing mammary gland proliferation. Empirically fenugreek containing diosgenin,
that caused breast enhancement. This research showed that treatment with
fenugreek extract can caused proliferation of mammary gland, both on imma-ture
and ovariectomized rats.
Key word: fenugreek,
phytoestrogen, mamae duct, ovariectomized rat, im-mature rat, Trigonella foenum
graecum L.
Penulis: Kurnia Agustini,
Sumali Wiryowidagdo, Dadang Kusmana
Kode Jurnal: jpfarmasidd070005
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